By Q. Varek. Lubbock Christian University. 2019.
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The translation here submitted to the public is the second translation of this work into English, it having before this been rendered by Dr. When it was proposed to reprint this translation, there was a strong protest made against the old version on the ground of its being to some degree inexact, and on account of its omitting not only the initials of the provers but besides this, also a great number of symptoms. These complaints have been proved well founded, especially with respect to the latter part of the work. We have taken a hundred symptoms at random here and there and compared them with the original, with the following results : in Alumina 555-655 we found only the omission of a part of symptom 556 and a partial omission and joining together of symptoms 617 and 618. So also in Graphites there is no omission except 53 (a repetition) in the first hundred, nor any other until we reach 200, 201 and 202 which are omitted. In the first hundred of Nitri acidum, however, we find 13 omissions, namely 6, 30, 32, 37, 38, 40, 43, 45, 59, 64, 65, 67 and 69. Between 1236 and 1335 there are 23 omissions, namely 1245, 1269, 1278, 1288, 1290, 1292, 1293, 1294, 1297, 1298, 1299, 1302, 1303, 1305, 1306, 1308, 1313, 1316, 1320, 1324, 1331, 1332, 1335, while one-half of the substance of symptoms 1287, 1296, 1312, 1315 and 1325 is omitted ; showing the omission in this extreme case of over one-fourth. The omissions are rather impartially distributed, about one-third of the above omissions being symptoms of Hahnemann, fully one-third, those due to Nenning and the other third, distributed impartially among the various other provers. These omissions made a new translation necessary, which was accordingly made independent of that of Dr. Hempel, though the earlier translation was consulted especially where there was any obscurity or ambiguity in the original. There is no question but that Hempel is right in what he says of the involved phraseology and the lengthy periods of Hahnemann ; still we did not think it best to follow his mode of rendering, which according to his preface consists in "mastering the sense of a period, and then embodying it in a free manner in the foreign tongue". Dudgeon in his admirable translation of the Materia Medica Pura (London, 1880) ; he has faithfully rendered not only the ideas but also the expressions of Hahnemann. We have accordingly preserved the long periods of Hahnemann and his own precise, if sometimes redundant, phraseology ; though, of course it was necessary to invert the periods and to arrange the phrases into the English order. This applies chiefly to the first theoretic part of the work, and in this part we would especially acknowledge the able assistance of Dr. Pemberton Dudley, who has taken care that too close a clinging to the German original might be avoided. We have generally endeavored to translate the same German word by the same English word, except where words have several meanings. Dudgeon with "pressive" or with "aching", we have uniformly rendered with pressive ; while we use "ache" to translate the German weh. There are a few words which require a varied translation according to the context : Brust is used both for "chest" and for "the female breast", so that e. We have taken care to translate these terms according to the context in every case, though the learned reader will remember that in some of these cases there is a little ambiguity. One of the German terms which seems to have no good English equivalent is Eingenommen with respect to the head. It means literally "occupied" and describes the sensation produced in the head by a cold, where the parts are as it were benumbed and incapacitated from acting freely. We have usually rendered it with "benumbed feeling", though as none of these terms was quite satisfactory, we have also sometimes used "muddled feeling" or "obtuseness". As was done in the Materia Medica Pura published in London, so we have also in this work printed the names of old school authorities cited with small capitals, while the names of other provers are in italics, so that it may be seen at a glance, whether the symptom was produced by an intentional proving (or from clinical experience), or whether it was the result of accidental poisoning or an overdose by an observer of the old school. Richard Hughes, of Bath, England, who in the course of his researches found occasion to rectify the numbers referring to the pages, etc. These at his suggestion were at first merely entered in the translation instead of the figures given by Hahnemann ; but on second thought, it seemed more useful to give them among the other notes given by Dr. While there seemed to be no necessity for an index to the Antipsoric Medicines, since this is furnished in the various repertories, especially in that of Bœnninghausen, it was thought useful to have an index to the first or theoretical part, and this was accordingly prepared by the translator. I shall do this mainly by notes appended to each pathogenesis ; but in the present place I desire to state what is known in a general way about the symptom-lists in question, [*] and what I propose to do for them as they severally appear in the following pages. In 1821 Hahnemann had been compelled to leave Leipsic, and, in difficulty where to find a place in which he could practice in freedom, had been offered an asylum in the little country town of Cœthen. He now ceased to attend acute disease, save in the family of his patron, the reigning Duke. But his fame brought him for consultation chronic suffers from all parts ; and the varied, shifting, and obstinate morbid stated under which so many men and women labour were pressed closely upon his attention. The result was the theory of chronic disease which (in its latest shape) will be found in these pages, and which traces so many of its forms to a "psoric" origin. To meet the manifold disorders thus induced it seemed to him that a new set of remedies were required. Accordingly, of the three volumes of the first edition of the present work published in 1828, the two latter contained what seem to be pathogeneses of fifteen medicines hitherto strange to his Materia Medica Pura, and in some cases to any Materia Medica whatever. These medicines were : Ammonium carbonicum, Baryta carbonica, Calcarea carbonica, Graphites, Iodium, Lycopodium, Magnesia carbonica, Magnesia muriatica, Natrum carbonicum, Nitri acidum, Petroleum, Phosphorus, Sepia, Silicea, Zincum. The pathogeneses of the foregoing (I assume them to be such from the analogy of the corresponding symptom-lists of the Materia Medica Pura ; but they are not avowedly so) appear without a word of explanation as to how the symptoms were obtained, and without acknowledgement (as in the previous work) of fellow-observers. The absence of any co-operation on the part of others is further to be inferred from what we are told of the first announcement of the work. After six years of solitude at Cœthen, Hahnemann "summoned thither his two oldest and most esteemed disciples, Drs. Stapf and Gross, and communicated to them his theory of the origin of chronic disease, and his discovery of a completely new series of medicaments for their cure". That he should now first reveal these new remedies, and in the following year should publish copious lists of their pathogenetic effects confirms the inference to be drawn from his position and from his silence as to fellow-observers. He was himself between seventy and eighty years old, and it is hardly likely that he did anything at this time in the way of proving on his own person. We are compelled to the conclusion that he drew these symptoms mainly -if not entirely- from the sufferers from chronic disease who flocked to his retreat to avail themselves of his treatment. The prefatory notices to the several medicines still further substantiate this view, and throw some light on the doses with which the symptoms were obtained. He recommends all the medicines to be given in the dilutions from the 18th to the 30th (save Magnesia muriatica and Natrum carbonicum, of which he advises the 6th and 12th respectively) ; and repeatedly makes some such remark as this : "For a long time past I have given the 6th, 9th and 12th potencies, but found their effects too violent". Occasionally, too, he must have used the second and third triturations ; as he speaks of having begun by giving a "small portion of a grain" of these, but, as this was an indefinite quantity, having subsequently dissolved and attenuated them. He mentions cases, moreover, in which he treated itch with Carbo vegetabilis and Sepia of the latter strength. We may conclude, therefore, that it is these "violent effects" of the attenuations from the 2nd to the 12th, experienced by the sufferers from chronic disease who took them, which make up the bulk -if not the whole- of the symptoms of the first issue of the Chronic Diseases. In 1830 there appeared a third volume (making the fourth of the first edition) of symptom-lists, appended to two more new medicines -Kali carbonicum and Natrum muriaticum, and to five others- Carbo animalis and vegetabilis, Causticum, Conium and Sulphur -which had already found place in the Materia Medica Pura.
To be able to describe bundle branch block and functional bundle branch block (aberrancy) discount levitra plus 400mg with amex. To be able to describe the differential diagnosis and appropriate evaluation of the patient with syncope purchase levitra plus 400mg amex. To be able to describe general function and indications for permanent pacemaker implantation 400mg levitra plus fast delivery. To be able to describe the general function and indications for implantable defibrillators. Sinus arrest may be due to changes with aging or fibrosis in the sinus node, damage to the sinus node blood supply, surgical injury, severe electrolyte abnormalities, or drugs (calcium channel blockers, beta receptor blockers). While they generally are premature (before the normal sinus beat would ordinarily have occurred), there also a series of ectopic beats called an escape rhythm that occurs when the normal impulse does not occur at a fast enough rate. These secondary pacemakers have intrinsic rates that are significantly slower than the sinus node and are normally suppressed by the sinus node. Premature ectopic beats are generally due to abnormal automaticity or pacemaker activity, which can be caused by metabolic or electrolyte abnormalities. It can be caused by acute ischemia, drugs, chronic degenerative changes, inflammation, chronic ischemia or fibrosis. Ectopic premature beats may also be caused bytriggered activity, which is a term used to describe an arrhythmia caused by afterdepolarizations. Afterdepolarizations are caused by oscillatory changes of the membrane potential that depend on preceding electrical activity (needs a trigger). There are two types of afterdepolarizations based on the timing of the afterdepolarizations with respect to repolarization,: (1) early afterdepolarizations which occur prior to completion of repolarization, and (2) late afterdepolarizations, which occur following full repolarization. It should be kept in mind that this categorization is an oversimplification of a very complex group of arrhythmias exhibiting a full spectrum of afterdepolarizations occurring anywhere within and after repolarization, and that the disorder can be attributed to disturbances of several ion channels. The one common theme of these arrhythmias is their dependence on a prior depolarization. Early afterdepolarizations: This activity, typically occurring during phase 2 and 3 of repolarization, can be caused by any intervention in which inward (depolarizing) current exceeds outward (repolarizing) current. Reduced potassium conductance can be caused by some potassium- blocking drugs (quinidine, sotalol). When such oscillatory activity reaches threshold potential it can cause a premature contraction (Figure 1) or a burst of tachycardia. Figure 2 One clinical entity seems to fit this mechanism, the polymorphic ventricular tachycardia known as torsade de pointes (twisting of the points) (Figure 2). Because the occurrence of afterdepolarization is not uniform throughout the ventricle, the delay in repolarization causes unpredictable, chaotic dispersion of recovery, resulting in reentry with a constantly moving pattern. This arrhythmia is commonly drug-induced (quinidine and other antiarrhythmics) or due to electrolyte abnormalities (hypokalemia and/or hypomagnesemia). Delayed afterdepolarizatlons: This abnormality, which was first noted in the setting of digitalis toxicity, is believed to be due to excess in intracellular calcium causing abnormal inward current. Digitalis, by blocking the Na+-K+ pump causes an increase in Arrhythmias - Paul J. The increased level of intracellular Ca++ is believed to alter membrane permeability allowing inward movement of mostly Na+ ions. Increased intracellular Ca++ can also be caused by catecholamines, which are known to enhance conductance through L-type Ca++ channels. Unlike early afterdepolarizations, the magnitude of delayed afterdepolarizations increases with higher rates of preceding depolarizations (Figure 3) because with increasing frequency of depolarization, there is an accumulation of intracellular Ca++. Reentry: Reentry is by far this is the most common type of arrhythmia in the clinical setting, and because of its self-sustaining characteristics. It simply requires the presence of conduction disparity between tissue sites whereby an area of slower conduction would initially block a premature impulse and later allow it to reenter, setting up a self-sustaining loop (Figure 5). It should be noted that the conduction delay or block may not necessarily be created by a fixed, structural abnormality. A simple disparity of conduction due to physiologic or pathologic anisotropy is sufficient to cause reentry. More commonly, areas of slow conduction occur as a result of tissue pathology, such as heterogeneity in areas of healed myocardial infarction or cellular hypertrophy and fibrosis from cardiomyopathy. The latter conditions are usually present in patients with reduced left ventricular function and the arrhythmia is frequently fatal. It is estimated that sudden death from fatal ventricular tachycardia and/or fibrillation affects over 400,000 people in the U. Ventricular tachycardia and ventricular fibrillation are the most "malignant arrhythmias. To effectively treat reentry arrhythmia, the slow conduction should be corrected or the alternate pathway eliminated or both. This should really not surprise anyone because drugs that are aimed at blocking any of the ionic channels may actually make the situation worse. Beta blockers and calcium-channel blockers have limited effect on the atrial and ventricular myocardium. The Na+- channel blockers may further slow conduction (and not surprisingly, some are indeed "proarrhythmic"). K+-channel blockers offer some promise because by prolonging recovery, they may terminate reentry. For supraventricular tachycardias, the definitive therapy usually requires the elimination (ablation) of the altemate pathway or key elements of the reentry circuit. The most effective immediate therapy for life threatening reentrant ventricular tachycardias is electrical cardioversion. By using a large transthoracic voltage it is possible to depolarize the entire heart muscle and thereby abolishing discrepancies in conduction that are essential for reentry. Some of the commonly encountered reentry arrhythmias that constitute distinct clinical entities and will be discussed below. This is called the Sinus Rhythm, occurring at rates from 60 to 100 beats per minute. The rate of the sinus node impulse formation is influenced by sympathetic and parasympathetic regulation. Self Study Question #1 Normal sinus rhythm occurs at rates from _____ to _____ beats per minute. Abnormalities of Sinus Rhythm Two abnormalities of sinus rhythm are sinus bradycardia and sinus tachycardia. While described as an arrhythmia, sinus bradycardia frequently occurs normally during sleep, in young adults and in athletes. This may result in symptoms of lightheadedness and loss of consciousness, and may require a permanent pacemaker (see therapy section below). Sinus tachycardia occurs when the sinus rhythm is greater than 100 beats per minute. Therefore, causes for sinus tachycardia should be investigated, but by itself does not require treatment in most situations. Study Question #2 As sympathetic stimulation increases, sinus _____________ can occur. Atrial Fibrillation occurs when there is rapid chaotic disorganized electrical activity in the atria due to multiple wavefronts.
Contamination of food is known buy 400 mg levitra plus visa, and unsuspecting persons have used wine and honey made from the plants purchase levitra plus 400mg on line. Rats on a 90-day diet including jimson weed seed experienced lower cholesterol levels purchase 400 mg levitra plus with visa, less weight gain, and increased weight of livers. Investigators running the experiment described the consequences of chronic jimson weed seed diet as undesirable, but of course humans do not eat the seeds as a regular food. Horses, cattle, and pigs react badly to jimson weed, but rabbits and sheep are relatively unaffected. Europeans were using Datura plants such as jimson weed in the 1500s; one account from that era mentions long-lasting intoxication with emotions ranging from euphoria to weeping, with people having amnesia about what they did while under the inﬂuence. The same account mentions prostitutes using Datura to make clients more pliable, and old reports speak of sexual frenzy induced by the substance. During the 1600s soldiers sent to suppress Bacon’s Rebellion in colonial Virginia partook of jimson weed, and according to an account dating from 1722, some were incapacitated for days: “One would blow up a Feather in the Air; another would dart Straws at it with much Fury; and another stark naked was sitting up in a Corner, like a Monkey, grinning and making Mows [grimaces] at them; and a Fourth would fondly kiss, and paw his Companions, and snear [sic] in their Faces. Marines at Camp Pendleton were treated for 208 Jimson Weed hallucinations from recreational jimson weed usage. A few years earlier a sur- vey of drug users in the South African military found about 3% to be using jimson weed. Some jimson weed users describe sensations of ﬂying, instant travel between one city and another, and communication with plants and inanimate objects. Although insects are a commonly reported visual hallucination from jimson weed, one uncommon sensation is a feeling of crawling insects, reminiscent of the “coke bugs” hallucination associated with cocaine. In keeping with an old but largely abandoned tradition of medicine, an articulate medical journal author engaged in Datura self- experimentation and produced a graphic account of interactions with charms of nineteenth-century Paris and with horrors of twentieth-century monsters. A witness later “told me that I fought the restraining devices so violently that he thought every blood vessel in my face and neck would explode. The Ames test, a standard laboratory procedure that screens sub- stances for carcinogenicity, indicates jimson weed seeds have potential for causing cancer. Birth defects did not become more common in children of 450 pregnant women who received the atropine component of jimson weed. The same lack of effect on congenital abnormalities was observed in a similar number of pregnancies after the women used the scopolamine component of jimson weed, a ﬁnding consistent with a rodent study. Jimson weed is botanically classiﬁed as the stra- monium species of the Datura genus. Other Datura genus plants around the world are used for similar effects, but they are not jimson weed. Johnson, “Mystical Force of the Nightshade,” International Journal of Neuro- psychiatry 3 (1967): 272. The substance was invented in the 1960s and was used as an anesthetic for Vietnam War combat casualties; it has been routinely used for war injuries ever since. Third World physicians report the drug is safe for surgical use outside high-tech environments. Ketamine is also a veterinary anesthesia drug used with wild animals ranging from giraffes and gazelles to polar bears and arctic foxes. Two researchers reported that ketamine therapy with 42 alcoholics produced a two-year abstinence from drinking in 15 of them, an outstanding result. Other researchers report one-year abstinence in almost 66% of 111 al- coholics who received ketamine therapy (perhaps a single dose), as opposed to 24% in 100 who did not receive ketamine. Among the 111 in the original group, 81 were tracked for two years, and 40% of the 81 remained abstinent. Admittedly they are related to self-insights Ketamine 211 prompted by the substance and guided by psychotherapists, but in principle a single dose of a drug is unlikely to stop addiction to some other drug. Experiments indicate ketamine may have potential for treating migraine headache and depression, and researchers have seen evidence that ketamine may improve asthma and shrink breast cancer cells. Ketamine can reduce phantom limb pain, a strange afﬂiction in which a person senses that an am- putated limb is still present and hurting. The drug has been used in psycho- therapy to help persons face and deal with unpleasant memories, a process accompanied by what researchers described as “mind expanding effects. Researchers have described such effects as “profound” among alcoholics, and illicit ketamine users have said such effects are “intense. Users may feel like their bodies are transforming into harder or softer substances. Some users take the drug to enter the “K-hole,” a semiparalytic state described as similar to near-death experiences in which people perceive their conscious- ness as ﬂoating above their bodies, sometimes accompanied by meaningful hallucinations and by insights about the user’s life and its proper place in the cosmos. Examination of deaths among recreational ketamine users in New York City in a two-year period during the 1990s found none in which ketamine was the only substance in the person’s body. Children have accidentally been given 5 to 100 times the normal size dose and have survived with no apparent injury. Nausea and vomiting have been reported, and scientiﬁc literature contains several mentions of temporary breathing interruption caused by the drug. Increased pressure within the eye (a potential problem for glaucoma sufferers) has been measured following a ketamine dose, but not all research- ers looking for that effect have found it. The drug can interfere with a male’s physical ability to engage in sexual activity. Experiments show that ketamine can cause brain damage in rats and that simultaneous use of nitrous oxide worsens the damaging action. Ketamine can cause nervous agitation, extra salivation, blood pressure elevation, abnormal heartbeat, and muscle injury. Persons suffering from the body chemistry disorder porphyria should exercise caution about ketamine use. Tests indicate ke- tamine can alter visual perception for at least 24 hours, causing people to misjudge size and speed of objects (implying that driving skills may be im- paired). Long-term use may cause persistent difﬁculties with attention, mem- ory, and learning ability. The substance can create amnesia about what happens while a person is under the drug’s inﬂuence. Ketamine’s psychological actions have been characterized as similar to tem- porary schizophrenia. A study examining persons who received the drug dur- ing surgery found that upon awakening some felt they were ﬂoating; some 212 Ketamine were euphoric; some screamed in apparent terror. The ﬂoating sensation may occur as people regain consciousness before they regain sense of touch, a sequence that would tem- porarily eliminate awareness of gravity. Reports exist of patients experiencing psychological effects for a year after a dose. A re- viewer who examined many years of scientiﬁc reports about ketamine, how- ever, found a consensus that long-term psychological consequences from ketamine occur no more frequently than with other anesthetics—a conclusion about incidental effects from anesthetic use, not about deliberate effects in- duced as part of psychotherapy or illicit use. One authority claims that the greatest physical hazard has a psychological base, as users sometimes become indifferent about death and take risks they would otherwise avoid. Persons intoxicated with ketamine may be woozy and have lower perception of pain, conditions that can cause or worsen accidents. While the male-female difference does not necessarily carry over to humans, use of ke- tamine’s anesthetic properties by sexual predators seeking to weaken victims was publicized in the 1990s.
Using these concepts levitra plus 400mg otc, it is possible to derive the equations that describe the behavior of matter as a function of temperature purchase 400 mg levitra plus visa. The theory considers a gas made of small particles (atoms or molecules) which are in continuous random motion discount levitra plus 400mg. Each particle travels in a straight line until it collides with another particle or with the walls of the container. The colliding particles exchange energy not only among themselves but also with the wall of the container (Fig. For example, if initially the walls of the container are hotter than the gas, the particles colliding with the wall on the average pick up energy from the vibrating molecules in the wall. As a result of the wall collisions, the gas is heated until it is as hot as the walls. This is an equilibrium situation in which, on the average, as much energy is delivered to the wall by the gas particles as is picked up from it. The speed and corresponding kinetic energy of the individual particles in a gas vary over a wide range. Still it is possible to compute an average kinetic energy for the particles by adding the kinetic energy of all the individual parti- cles in the container and dividing by the total number of particles (for details, see [11-7]). Many of the properties of a gas can be simply derived by assum- ing that each particle has this same average energy. The internal energy in an ideal gas is in the form of kinetic energy,1 and 1 2 therefore the average kinetic energy mv is proportional to the tem- 2 av perature. The proportionality can be changed to an equality by multiplying the temperature T by a suitable constant which relates the temperature to the internal energy. The constant is designated by the symbol k, which is called 1The simple theory neglects the vibrational and rotational energy of the molecules. For historical reasons, Boltzmann constant has been so 3 deﬁned that it has to be multiplied by a factor of to relate temperature to the 2 average kinetic energy of a molecule; thus, 1 2 3 mv kT (9. The size of the degree division on the absolute scale is equal to the Celsius, or centigrade, degree, but the absolute scale is transposed so that 0◦C 273. Since our calculations are carried only to three signiﬁcant ﬁg- ures, we will use simply 0◦C 273◦K. The pressure exerted by a gas on the walls of its container is due to the numerous collisions of the gas molecules with the container. One calorie (cal) is the amount of heat required to raise the temperature of1gofwater by 1 C◦. In the life sciences, heat is commonly measured in kilocalorie units, abbreviated Cal; 1 Cal is equal to 1000 cal. With 75% water and 25% protein, the speciﬁc heat of the body would be Speciﬁc heat 0. The latent heat of fusion is the amount of energy required to change1gofsolid matter to liquid. The latent heat of vaporization is the amount of heat required to change1gofliquid to gas. In this case, heat has been transferred from the ﬁre through the rod by conduction. The process of heat conduction involves the increase of internal energy in the material. The heat enters one end of the rod and increases the internal energy of the atoms near the heat source. In a solid material, the internal energy is in the vibration of the bound atoms and in the random motion of free electrons, which exist in some materials. The addition of heat increases both the random atomic vibrations and the speed of the electrons. The increased vibrational motion is transferred down the rod through collisions with neighboring atoms. In some materials, the electrons in the atoms have enough energy to break loose from a speciﬁc nucleus and move freely through the material. The elec- trons move rapidly through the material so that, when they gain energy, they transfer it quickly to adjacent electrons and atoms. In this way, free electrons transfer the increase in the internal energy down the rod. Materials such as metals, which contain free electrons, are good conductors of heat; materials such as wood, which do not have free electrons, are insulators. However, for problems involving living systems, it is often more convenient to express K in units of Cal cm/m2-hr-C◦. This is the amount of c heat (in Cal units) per hour which ﬂows through a slab of material 1 cm thick and 1 m square per C◦ temperature diﬀerence between the faces of the slab. Fluid from the denser region ﬂows into the rareﬁed region, causing convection cur- rents. When the ener- getic molecules in the heated convection current come in contact with a solid material, they transfer some of their energy to the atoms of the solid, increasing the internal energy of the solid. The amount of heat transferred by convection per unit time Hc is given by Hc KcA(T1 − T2) (9. Electromagnetic radi- ation is itself energy (called electromagnetic energy), which in the case of a moving charge is obtained from the kinetic energy of the charged particle. Because of internal energy, particles in a material are in constant random motion. Both the positively charged nuclei and the negatively charged elec- trons vibrate and, therefore, emit electromagnetic radiation. In this way, inter- nal energy is converted into radiation, called thermal radiation. The amount of radiation emit- ted by vibrating charged particles is proportional to the speed of vibration. Because the elec- trons are much lighter than the nuclei, they move faster and emit more radiant energy than the nuclei. At high temperatures, some of the electromagnetic radiation is in the visible region, and the body is observed to glow. When electromagnetic radiation impinges on an object, the charged par- ticles (electrons) in the object are set into motion and gain kinetic energy. Other materials, such as quartz and certain glasses, transmit the radiation without absorbing much of it. Such reﬂecting and transmitting materials cannot be heated eﬃciently by radiation. The rate of emission of radiant energy Hr by a unit area of a body at temperature T is 4 Hr eσT (9. The temperature is measured on the absolute scale, and e is the emissivity of the surface, which depends on the temperature and nature of the surface.
It is also effective like aspirin and is used in analgesia for headaches (from weak to moderate pain) cheap levitra plus 400mg with mastercard, myalgia buy generic levitra plus 400 mg line, arthralgia purchase levitra plus 400 mg without a prescription, chronic pain, for oncological and post-operational pain, etc. The mechanism of action of this series of nonsteroid, anti-inflammatory analgesics is not conclusively known. It is frequently used in combination with the anticoagulant warfarin, the effect of which is strengthened when combined with flufenamic acid. Meclofenamic acid: Meclofenamic acid, N-(2,6-dichloro-m-tolyl)anthranylic acid (3. The mechanism of their action is not con- clusively known; however, it has been suggested that it is also connected with the suppression of prostaglandin synthetase activity. The simplest way to synthesize ibuprofen is by the acylation of iso-butylbenzol by acetyl chloride. Hydrolysis of the resulting product in the presence of a base produces ibuprofen (3. Ibuprofen exhibits analgesic, fever-reducing, and anti-inflammatory action compara- ble to, and even surpassing that of aspirin and acetaminophen. It is used in treating rheumatoid arthritis, in various forms of articular and nonarticular rheumatoid diseases, as well as for pain result- ing from inflammatory peripheral nerve system involvement, exacerbation of gout, neu- ralgia, myalgia, ankylosing spondylitis, radiculitis, traumatic soft-tissue inflammation, and in the musculoskeletal system. The most common synonyms for ibuprofen are brufen, ibufen, motrin, rebugen, and others. It causes reduction and removal of painful symptoms including joint pain, stiffness, and swelling in the joints. The carbonyl group of the resulting product is reduced by sodium borohydride and the resulting alcohol (3. Analgesics Fenoprofen is chemically and pharmacologically similar to the series of compounds described above. It is used in treating symptoms of rheumatoid arthritis and osteoarthritis; however, fenoprofen exhibits a number of undesirable side effects. The reduction of the resulting product by sodium cyanide gives 3-cyanomethylbenzophenone (3. It is also used for mild trauma; in particular, in sporting injuries such as sprains or ligament and muscle ruptures. It displays a number of undesirable side effects on hepatic and renal functions as well as on the gastrointestinal tract. It is supposed that their anti-inflammatory, analgesic, and fever-reducing action also is due to the suppression of prostaglandin synthetase activity. The reaction of these in the presence of sodium hydroxide and copper gives N-(2,6-dichlorophenyl)anthranylic acid (3. It is used in acute rheumatism, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, and myalgia. The resulting product is reacted with sulfur and morpholine according to Willgerodt method, giving thioamide (3. According to the first method, a reaction is done to make indole from phenylhydrazone (3. This product is hydrolyzed by an alkali into 5-methoxy-2-methyl-3-indolylacetic acid (3. The resulting product undergoes acylation at the indole nitrogen atom by p-chorobenzoyl chloride in dimethylformamide, using sodium hydride as a base. The resulting tert-butyl ester of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid (3. In order to do this, condensation of acetaldehyde with n-methoxyphenylhyrazine gives hydrazone (3. The product is methylated by methyl iodide, giving the corresponding quaternary salt (3. Reaction of the product with sodium cyanide gives 1-methylpyrrole-2-acetonitrile (3. Analgesics α-position of the pyrrole ring by 4-methylbenzoylchloride in the presence of aluminum chloride. It is used for relieving weak to moderate pain in rheumatoid arthritis and osteoarthritis. Reduction of the double bond by hydrogene using a palladium on carbon catalyst gives 4-fluoro-α-methyldihydrocinnamic acid (3. In the presence of polyphosphoric acid, the resulting product undergoes cyclization to 5-fluoro-2-methyl-3- indanone (3. The resulting ketone undergoes a Knoevenagel reaction with cyanoacetic acid and is further decarboxylated into 5-fluoro-2-methyliden-3-acetic acid (3. Condensation of the product with n-mercaptobenzaldehyde in the presence of sodium methoxide gives 5-fluoro- 2-methyl-1-(4-methylthiobenzyliden)-3-indenacetic acid (3. It usually comes from toluene, which is sulfonated by chlorosulfonic acid, forming isomeric 4- and 2-toluenesulfonyl chlorides. This undergoes diazotization using nitrous acid, and the resulting diazonium salt (3. Reaction of the resulting product with chlorine gives o-chlorosulfonylbenzoic acid methyl ester (3. In the presence of hydro- gen chloride, the resulting product undergoes cyclization into saccharin (3. The resulting product is reacted with methyl chloroacetate, giving the saccharin-substituted acetic acid methyl ester (3. Upon reaction with sodium methoxide in dimethylsulfoxide, the product undergoes 52 3. Analgesics rearrangement into 1,1-dioxide 3-methoxycarbonyl-3,4-dihydro-2-H-1,2-benzothiazin-4- one (3. Finally, reaction of the resulting product with 2-aminopyridine gives piroxicam (3. It is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases associated with inflammation. The most common type of insomnia is tran- sient insomnia due to acute situational factors. The primary indication for use of hypnotic agents in patients with insomnia is transient sleep disruption caused by acute stress. Soporific agents are drugs that facilitate the development and normalization of sleep. For approximately 100 years, bromides, followed by chloral hydrate, and subsequently bar- biturates were the only drugs capable of relieving patient conditions of insomnia and neu- rological disorders. From the chemical point of view, soporific, seda- tive, and hypnotic drugs are classified as barbiturates, benzodiazepine hypnotics, and so on. Except for a few rare exceptions, any one of these compounds can be used for acquir- ing a sedative effect or state of sleep. Presently, the less toxic benzodiazepines are edging out the class of barbiturates more and more because of the possibility of chronic depend- ence associated with the use of barbiturates.
Pre-treatment checks * Contraindicated in severe anaemia cheap levitra plus 400mg overnight delivery, "intracranial pressure due to head trauma or cerebral haemor- rhage buy levitra plus 400mg visa, uncorrected hypovolaemia and hypotensive shock cheap 400mg levitra plus amex, arterial hypoxaemia and angina caused by hypertrophic obstructive cardiomyopathy, constrictive pericarditis, pericardial tamponade or toxic pulmonary oedema. Withdraw 50mL of the 500 micrograms/mL strength into a syringe suitable for use with a syringe pump. Alternatively, withdraw 25mL of the 1mg/mL strength and make up to 50mL with NaCl 0. Inspect visually for particulate matter or discolor- ation prior to administration and discard if present. Pulmonary capillary wedge * To monitor therapeutic pressure, cardiac output and response. Additional information Common and serious All effects are reversible on infusion rate reduction or discontinuation. Also nausea, diaphoresis, restlessness, retrosternal discomfort, abdominal pain and paradoxical #pulse. Significant * The following may " isosorbide dinitrate levels or effect (or "side-effects): interactions other hypotensive drugs; phosphodiesterase type-5 inhibitors (sildenafil is contraindicated). This assessment is based on the full range of preparation and administration options described in the monograph. Itraconazole | 477 Itraconazole 10mg/mL solution in 25-mL vials (with 50mL NaCl 0. Dose in hepatic impairment: use with caution only if benefit exceeds the risk of hepatic injury. Intermittent intravenous infusion Vials (and prepared infusions) contain an overage. Inspect visually for particulate matter or discolor- ation prior to administration and discard if present. Attach a standard infusion line to the infusion bag and fill the drip chamber to half full by squeezing (pumping) it. Exposure to normal room light during infusion is acceptable, but protect from direct sunlight. Administer 60mL only of the solution over 60 minutes then stop the infusion (this provides the 200-mg dose). Stability after Protect from direct sunlight during infusion -- exposure to normal room light preparation is acceptable. From a microbiological point of view, should be used immediately; however, prepared infusions may be stored at 2--8 C and infused (at room temperature) within 24 hours. Monitoring Measure Frequency Rationale Renal function 2--3 times weekly * A component of the formulation, hydroxypropyl- b-cyclodextrin, is eliminated through glomerular filtration and this causes the caution in renal impairment. Signs and symptoms Throughout treatment * If these occur, stop treatment immediately. Action in case of There is no specific antidote and it is not removed by haemodialysis. Counselling Patients should be told how to recognise signs of liver disorder and advised to seek prompt medical attention if symptoms such as anorexia, nausea, vomiting, fatigue, abdominal pain or dark urine develop. This assessment is based on the full range of preparation and administration options described in the monograph. Adose of 4mg/kg isused for diagnostic manoeuvres and procedures not involving intense pain. Intramuscular injection Preparation and administration Check that you have selected the correct strength of vial. Ketamine | 481 Intravenous injection Preparation and administration Check that you have selected the correct strength of vial. Inspect visually for particulate matter or discoloration prior to administration and discard if present. Continuous intravenous infusion Preparation and administration Check that you have selected the correct strength of vial. Add the ketamine to the prepared infusion bag to give a solution containing 1mg/mL. Inspect visually for particulate matter or discoloration prior to administration and discard if present. Therateofinfusionisdependent on the patient’s reaction and response to anaesthesia. Fluid restriction: solutions containing up to 50mg/mL have been used (unlicensed). The drug may darken on prolonged exposure to light; this darkening does not appear to affect potency. Respiratory Post administration * May occur with over-rapid administration depression or overdosage of ketamine. Additional information Common and Immediate: Anaphylaxis has been reported rarely. Significant Barbiturates or narcotics may "ketamine levels or effect (or "side-effects) (prolonged interactions recovery time). This assessment is based on the full range of preparation and administration options described in the monograph. Technical information Incompatible with Not relevant Compatible with Not relevant pH Not relevant Sodium content Nil Excipients Contains benzyl alcohol. Additional information Common and serious Immediate: Anaphylaxis and other hypersensitivity reactions may occur. Action in case of Antidote: No known antidote; stop administration and give supportive therapy overdose as appropriate. This assessment is based on the full range of preparation and administration options described in the monograph. Pre-treatment checks * Avoid in active or previous peptic ulcer, cerebrovascular bleeding, haemorrhagic diatheses, the complete or partial syndrome of nasal polyps, angioedema or bronchospasm, hypovolaemia or dehydration, moderate or severe renal impairment (Cr >160 micromol/L) and severe heart failure. Inspect visually for particulate matter or discoloration prior to administration and discard if present. Monitoring Measure Frequency Rationale Reduction of pain Postoperative * To ensure that treatment is effective. Additional information Common and serious Immediate: Anaphylaxis and other hypersensitivity reactions may occur. This assessment is based on the full range of preparation and administration options described in the monograph. Patients for whom halothane is contraindicated usually requireahigherinitialdoseof 25--30mg. The dose may be doubled every 30 minutes until a satisfactory response or a dosage of 160mg/hour is reached. Inspect visually for particulate matter or discolor- ation prior to administration. Continuous intravenous infusion Preparation of a 1mg/mL solution (other strengths may be used) 1. Withdraw and discard 10mL from a 250-mL infusion bag containing compatible infusion fluid (usually Gluc 5%). Withdraw300mg(60mL)oflabetalolinjectionsolutionfromthreeampoulesusingasyringeandadd to the remaining 240mL of infusion fluid and mix well.
Fungal (mycotic) infections cause a lot of discomfort buy 400 mg levitra plus free shipping, and as a rule purchase levitra plus 400mg fast delivery, are difficult to cure buy levitra plus 400 mg cheap. Fungal infections are conventionally divided into three categories: dermatophylic, mucocutaneous, and systemic. The most widespread are dermatophytic fungal infections, which include skin, hair, and nails. Most infections can be cured by using topical drugs, such as tolnaftate, undecylenic acid, haloprogin, clotrimazole, and miconazole. Griseofulvin is used orally for deep infec- tions, in particular for infections of the nail bed. Mucocutaneous infections caused primarily by the fungus Candida albicans occur in regions of moist skin and mucous membranes (i. Amphotericin B, miconazole, clotrimazole, and nystatin are used topi- cally to treat such infections. Systemic fungal infections are very rare, although they do present a serious problem since they are naturally chronic and difficult to diagnose and treat. So, antifungal drugs are medications used to treat fungal infections such as athlete’s foot, ringworm, and candidia- sis (thrush) as well as serious systemic infections like cryptococcal meningitis. Antifungals work by exploiting differences between mammalian and fungal cells to kill the fungal organism and without significantly harming the host. From the chemical point of view, antifungal drugs can be divided into polyenes, imida- zole and triazole derivatives, allylamines, and others. The polyenes (nystatin, amphotericin B, natamycin) bind with sterols in the fungal cell wall, principally ergosterol. Human (and other animal) cells contain cholesterol rather than ergosterol so are much less susceptible. The imidazole and triazole groups of antifungal drugs (imidazoles: miconazole, ketoconazole, clotrimazole, econazole, mebendazole, butoconazole, fluconazole) inhibit the enzyme cytochrome P450 535 536 35. This enzyme converts lanosterol to ergosterol, and is required in fungal cell-wall synthesis. Allylamines (naftifine, terbinalfine, butenafine, amorolfine) inhibit the enzyme squalene epoxidase, another enzyme required for ergosterol synthesis. Others: Griseofulvin binds to polymerized microtubules and inhibits fungal mitosis. From the medical point of view, antifungal drugs are con- sidered dermatophytic, mucocutaneous, and systemic. Amphotericin B: Amphotericin B, [1R(1R∗,3S∗,5R∗,6R∗,9R∗,11R∗,15S∗,16R∗,17R∗, 18S∗,19E∗,21E∗,23∗,25E∗,27E∗,29E∗,31E∗,33R∗,35S∗,36R∗,37S∗)]-33-[3-amino-3,6- dideoxy-β-D-mannopyranosyl)-oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl- 13-oxo-14,39-dioxabicyclo [33. The antifungal activity of amphotericin B is exhibited because it binds with sterols, in particular with ergosterol in the cellular membrane of sensitive fungi. This reaction makes pores in the membrane and increases the perme- ability of the membrane to small molecules, thus reducing the function of the membrane as an osmotic barrier and making the cells more sensitive to being destroyed. However, this compound is not highly selective and reacts with host mammalian cells. Despite the many side effects, amphotericin B remains the primary drug for treating severe, acute systemic fungal infections. It is used for generalized fungal infections, such as can- didomycosis, aspergillosis, histoplasmosis, cryptococcosis, coccidioidomycosis, blasto- mycosis, and pulmonary mycoses. The mechanism of antifungal activity is similar to the mechanism of action of ampho- tericin B. It is used for preventing and treating candida infections of the skin and mucous membranes. In terms of preventative action, it is used for preventing the development of candidomycosis during prolonged treatment with penicillin drugs and antibiotics of other group, especially during oral use of tetracycline antibiotics, levomecytin, and others. Synonyms of this drug are biofanal, moronal, nicporil, fazigin, candex, and others. Natamycin: Natamycin, a mixture of stereoisomeric 22-[(3-amino-3,6-dideoxy-β-D- mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricy- clo[22. It exhibits especially pronounced activity against a few strains of Fusarium and Cefalosporium. Natamycin is a drug for treating superficial fun- gal infections, and it is used only for ophthalmologic purposes. They are ketoconazole, miconazole, clotrimazole, econazole, butoconazole, and others. Antifungal Drugs The antifungal activity of imidazole derivatives is currently explained by their ability to selectively raise the permeability of the membrane of fungal cells by interfering with the biosynthesis of sterins, in particular ergosterin, by inhibiting its synthesis and by changing the lipid content of the membrane. However, unlike amphotericin B, benzimidazole deriv- atives are active only against growing cells. This drug does not affect host cells because mammals use exogenic sterols for their vital functions. Acylating the hydroxyl group of this compound with benzoyl chloride, and then alkylating the resulting compound with imidazole gives the derivative (35. Next, alkaline hydrolysis removes the benzoyl group, and a reaction with methanesulfonyl chloride gives a mesylate (35. Finally, alkylating the resulting 1-acetyl-4-(4-hydroxyphenyl)piperazine gives ketoconazole (35. It possesses fungicidal and fungistatic activity with respect to dermatophytes, yeast fungus, dimorphous fungi, and eumycetes. It is effective for chronic diseases, treating fungal infections of the gas- trointestinal tract, sex organs, skin, hair, and nails. It is used in combination with shampoo for treating and preventing mycelial fungi, seborrheic dermatitis, and dandruff. Reducing the carbonyl group in this molecule with sodium borohydride gives 1-(2,4-dichlorophenyl)-3-(1-imidazolyl)-ethanol (35. It differs in the presence of a single chlorine atom in the benzyl part of the molecule, and it is synthesized in the same manner, except that it uses 4-chlorobenzylchloride in the last stage instead of 2,4-dichlorobenzylbromide [22–24]. It differs in the replacement of the etheral oxygen bridge (which connects the 4-chlorobenzyl part of the molecule with phenethylimidazole) for a thioether bond. The corresponding changes in the synthesis of this drug are the replacement of the hydroxyl group in 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)-ethanol (35. The hydroxyl group in the last is replaced with a chlorine atom upon reaction with thionyl chloride, which is then by the reaction with 2,6- dichlorothiophenol butoconazole [27,28], is obtained. It is believed that butocona- zole, like miconazole, econazole, and other “pure” representatives of the imidazole class, also inhibits the biosynthesis of estrosterin in the cytoplasmatic membrane of fungi; how- ever, it is very possible that this is not the only mechanism of its action. It is synthesized from 2,4-dichloroacetophenone, which is reacted with glycerol in the presence of p-toluenesulfonic acid to make a ketal, 2-(2,4-dichlorophenyl)- 2-methyl-4-hydroxymethyl-1,3-dioxolane (35.
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