By J. Zarkos. Hillsdale College.

Moist heat sterilisation (steam autoclaves) – Trays of surgical instruments Dry heat sterilisation – Non-aqueous liquids and ointments Ionising radiation – Swabs cardizem 180 mg on-line, catheters cheap 120mg cardizem with visa, syringes Ethylene oxide – Sutures purchase cardizem cheap, electrical equipment Formaldehyde – Plastics Glutaraldehyde – Endoscopes Does sterilisation destroy prions? All instruments need to be cleaned and thoroughly dried before they are sterilised. There are three main cleaning methods: Hand scrubbing, ultrasonic cleaning and automated washing. It has potent antiseptic activity against Gram-positive and Gram-negative organisms and some viruses, but only moderate activity against the tubercle bacillus. There is some activity against bacterial spores and good activity against tubercle bacilli. Iodine has some residual effects but these are not sustained for more than 4 hours. They are effective in destroying Gram-positive and Gram-negative bacteria, fungi, viruses and tubercle bacilli. Hands and forearms are washed systematically three times, the hands being held above the level of the elbows throughout. The folded gown is lifted away from the trolley and allowed to unfold (inside facing the wearer), whilst the top is held. Arms are inserted into the armholes simultaneously, hands remaining inside the gown until gloves are donned: the gown is secured by an unscrubbed staff member. Gloves are put on using a one- or two-person technique: From this point on, hands remain above waist level at all times. Anti-fungal Surgical iodine is not free but scrub in combined with dilute polyvinylpyrrolidone solutions in (povidone) open wounds Cetrimide Aqueous Handwashing Pseudomonas spp. Ammonium compounds have good detergent action (surfaceactive agent) Alcohols 70% ethyl, Skin Should be reserved for isopropyl preparation use as disinfectants Hypochlorites Aqueous Instrument Toxic to tissues preparations and surface (Eusol, cleaning Milton, (debriding Chloramine agent in T) open wounds) Hexachlorophane Aqueous Skin Has action against bisphenol preparation Gramnegative Handwashing organisms Figure 4. An antibiotic is a substance produced by or derived from a microorganism that destroys or inhibits the growth of other microorganisms. There is evidence to support the use of prophylactic antibiotics in clean- contaminated and contaminated operations. Biliary tract surgery – Risk factors include emergency surgery, > 70 years of age, jaundice, obesity, exploration of the common bile duct and concomitant alimentary procedures, biliary instrumentation without surgery (i. Colorectal surgery – Surgery involving the bowel has a high rate of primary or secondary sepsis associated with anastomotic dehiscence. Appendicectomy Vaginal or abdominal hysterectomy Urogenital surgery Exogenous contamination: Lower limb surgery in the presence of peripheral vascular disease Prosthetic joint replacements Prosthetic heart valves Neurosurgical shunts Extensive trauma and burns Surgical procedures and instrumentation in rheumatic and valvular heart disease Mesh insertion in hernia repair Host immune system suppression: Diabetes mellitus Chronic renal failure Leukaemia Aplastic anaemia Malnourishment Carcinomatosis Obstructive jaundice Steroids therapy (Figure 4. Choice of antibiotics for prophylaxis Empirical cover against expected pathogens with local hospital guidelines. Continue as therapy if there is unexpected contamination or if a prosthetic is implanted in a patient with a septic source. Benzylpenicillin should be used if Clostridium gas gangrene infection is a possibility. Patients with heart valve disease or a prosthesis should be protected from bacteraemia caused by dental work, urethral instrumentation or visceral surgery. Cardiovascular – Hypertension, angina and atherosclerosis Cerebrovascular – Stroke Peripheral vascular – Large blood vessel diseases (macroangiopathy), gangrene Renal – Uraemia and hypertension Eyes – Proliferative and non-proliferative retinopathies and cataracts Metabolic – Hyperglycaemia and ketoacidosis Nerves – Peripheral neuropathy (increased risk of pressure sores) Skin – Poor wound healing and infections How should a diabetic patient be managed during surgery? Full medical assessment is performed to evaluate diabetic control and identify potential complications. A patient should not fast for prolonged periods, they should be scheduled first on an operating list. Diet-controlled diabetic patients For minor surgery, no additional precautions are required. For major surgery, monitor blood glucose and if elevated commence an insulin sliding scale. Oral hypoglycaemic-controlled diabetic patients For minor surgery, the morning dose of the oral hypoglycaemic agent should be omitted. For major surgery, patient should be commenced on an insulin sliding scale when they are nil by mouth and stopped when they have resumed eating and drinking. Insulin-controlled diabetic patients For all surgeries, the insulin dose should not be given whilst the patient is fasted. Intra-operative period: Anaesthesia combined with surgical stress has a definite hyperglycaemic effect. Post-operative period: Aim to have the patient’s blood glucose levels within normal range. Oral fluids once started should be followed by a soft diet and then a diabetic diet. The patient was neuropathic but not ischaemic and it was possible to salvage a functional foot by ‘filleting’ the hallux and using the soft tissues to cover the defect. Whilst treating patients, we are commonly exposed to bodily fluids (including blood). This can occur with needle stick injuries, mucosal contact and bodily fluid spillages and splashes. Route Estimated infections/10,000 % exposures to an infected source Blood transfusion 9000 90 Needle-sharing 67 0. When there is a risk of splashing, particularly with power tools, use of a full face mask is recommended, or protective glasses. Use of fully waterproof, disposable gowns and drapes, particularly during seroconversion. A set protocol should be followed: Immediate action Following any exposure, the site is washed liberally with soap and water (without scrubbing). Exposed mucous membranes, including conjunctivae, should be irrigated copiously with water, before and after removing any contact lenses. Risk assessment This assessment needs to be made urgently by someone other than the exposed worker about the appropriateness of starting treatment. The decision for prophylaxis is based on the exposure potential, the type of body fluid or substance involved, and the route and severity of the exposure. There are two principles involved: Differential light absorption by deoxyHb and oxyHb at two wavelengths, usually 660 nm (red, where deoxyHb > oxyHb) and 940 nm (near infrared, where oxyHb > deoxyHb). Since the pulsating blood in the artery is the only substance that is changing, the stable substances (skin, tissue etc. Increased surgical bleeding (the enzymes in the clotting cascade are slowed down) Increased incidence of myocardial infarcts and arrhythmias (hypothermia and shivering increases oxygen consumption and vascular resistance) Delayed recovery from anaesthetic/prolonged drug metabolism Excessive sympathetic nerve stimulation on waking Negative nitrogen balance (protein catabolism) Impaired immune function Increased wound infection Patient discomfort Describe measures to reduce heat loss in patients undergoing surgery. The most likely reasons are sepsis (including the presence of an intra-abdominal collection), a pulmonary embolus or an anastomotic leak. Bleeding is unlikely at day 7 post-operative and also note the patient has an associated fever. This patient is acutely unwell and requires urgent resuscitation and investigation to determine the cause (Table 4. The system is composed of three allelic genes-A, B and O, which control synthesis of enzymes that add carbohydrate residues to the cell surface glycoprotein.

Large-caliber choroidal vessels arc visible in the region of atrophy generic cardizem 180mg line, while fluorescence from the choriocapillaris is still present along the edges of the clinically apparent atrophy (bottom row) purchase cheapest cardizem and cardizem. Note the sharply dem arcated lipofuscin figures in the m acula cost of cardizem, more so in the left eye than the right eye. The fluorescein angiogram shows blockage of fluorescence centrally due to the lipofuscin accum ulation a s well a s stammg of som e of the lipofuscin deposits. When consid­ ering patients with reticular pigmentary changes, though, other clinically more common syndromes such as mito­ chondrial macular dystrophies associated with maternal diabetes and deafness should also be considered, especially from the standpoint of systemic disease intervention. Ann Intern atrophic peripheral changes in addition to the macular Med 2001;131:721-8. A pcriphcrin/rctinal degen­ eration slow m utation (Pro-210-Arg) associated with m acular and detachments and deposition of lipofuscin. Arch Using autofluorescence, Spaide described pathophysiologic Ophthalm ol 1996;114:448-56. Br J locus on chromosome 5 indicates that there must be geno­ O phthalm ol 2007;91:1504-11. Arch even within a single extended family with the same disease- O phthalm ol 1999; 117:1373-83. While the overall prognosis is fairly the norm al product o f the gene responsible for retinal degeneration in the rds mouse. Prog subfoveal choroidal neovascularization secondary to reticular pattern Retin Eye Res 2008;27:213-35. Acta O phthalm ol Scand 1997; m utations in peripherin/R D S in autosom al dom inant m acular 75:22-7. Visual outcom e following sub­ m aculatus in a single family with a deletion of codon 153 or 154 of retinal hem orrhage in Best disease. Arch Ophthalm ol ity associated with a novel m utation of the retinal degeneration slow/ 2001;119:359-69. Intrafamilial phenotypic in patients with Stargardt disease and fundus flavimaculatus. Br J Ophthalm ol heterogeneity of butterfly-shaped pigm ent dystrophy of the lovea. Clinical features of diabetes mel- phy: a gcnctic, clinical, and histopathological report. Deposition of yellow subm acular m aterial in central serous study of three generations. Although glaucoma is an optic neuropathy and hereditary optic neuropathy cases from across the globe. The energy demands of the photo receptors arc greater tumor compressing the optic nerve. Thus, in most cases, than the retinal ganglion cell, but some feature of the mito­ neuroimaging is necessary. It is particularly important to chondria at the lamina cribrosa makes them susceptible. A thorough family history is vital and does not end with the first clinical consultation. Patients (or par­ Molecular diagnosis and extended-family studies have ents) should be asked to find out whether anyone else in the increased the number of individuals with optic atrophy extended family had or has any form of visual loss. A history of 1/50,000 in the French' and the Finnish populations,7 prematurity, or problems in pregnancy or the neonatal period 1/39,000 in the Netherlands,8 1/31,000 in northeast may suggest perinatal optic atrophy, which is often not England,9 and 1/12,500 in Tasmania. Even when the cause of optic atrophy appears obvious, it is wise to perform neuroimaging studies on virtually all patients to exclude a compressive lesion. Numerous other authors described cases and L e b e r stellate neuroretinitis pedigrees, with the first major review by Bell (1931),26 in which she provided details on over 600 patients. Several changes were proposed as primary muta­ tions but later found to be related to mitochondrial haplotypes—for example the 15257 mutation, which was not 3460 3:1 3. The addi­ population of 1 million children under 18 years) found no tional feature of diabetes insipidus was reported by Raiti cases. Barbet and associates1'’ reported a consanguineous and colleagues,169 and nerve deafness by Shaw and family of French origin in which four sibs were affected Duncan. Examination showed optic atrophy ates172 proposed that an inherited abnormality of thiamine with adult visual acuity ranging from 6/30 to 6/60. Lcsscll and Rosma175 described anosmia, 311050) tonic pupils, and disc cupping (Fig. Swift and collcagucs,7,; 177also associated urinary tract atony, periph­ X-linkcd optic atrophy, ОРЛ2 has been mapped to Xpl 1. A Dutch kindred with eight males in seven sibships atric illness, while Rando and coworkers178 added ataxia, o f three generations (connected through females) had optic nystagmus, and seizures. Page and associates179emphasized atrophy of early onset, perhaps present at birth. Swift plantar reflexes, dysarthria, tremor, dysdiadochokincsia, and colleagues176,1 reported that 25% of homozygous and difficulty with tandem gait. Optic discs were sharply outlined and com ­ greater risk of severe psychiatric disturbance. Multipoint link­ diabetes mellitus and optic atrophy should be investigated age analysis placed the gene in the Xpl 1. Diabetes insipidus may be An American family with six males affected with optic confirmed by using a water deprivation test for 8 hours and atrophy in three generations was reported. Intravenous pyel­ individuals had decreased visual acuity from early ography, voiding cystourethrography, and ultrasound may childhood; visual acuities ranged from 6/9 to 6/30, and all reveal dilatation o f the urinary tract. Female carriers were clin­ widespread atrophic changes throughout the brain, some ically unaffected. No other neurologic abnormalities o f which correlate with the major neurologic features of the were observed in any family members. Optic atrophy in children with diabetes may also occur the extended disease haplotype of this family was distinct because o f the random overlap of two disorders, or may be from that of the family described by Assink and secondary to papilledema. Invest O phthalm ol Vis Sci with spccial rcfcrcncc to the associated color-sense disorder). J Neurol Sci m utations on m itochondrial m orphology and apoptosis: relevance 1978;38:11-21. Am J O ptom Arch Am responsible for autosom al dom inant optic atrophy and cataract. Histopathology of eye, optic nerve m urine O pal gene features pathology of autosom al dom inant optic and brain in a ease of dom inant optic atrophy. Reccssivcly inherited, simple optic atrophy—docs it encoding a m itochondrial dynam in-rclated protein, is m utated in exist? A family with in a dom inant optic atrophy family: evidence that haploinsulli- apparently sex-linked optic atrophy.

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Plug tions as well as maintain resistance to infection while being extrusion clearly accounts for a significant number of early rapidly absorbed by host tissues after stimulating tissue postoperative failures with a 0–41 % extrusion rate reported ingrowth buy 180 mg cardizem with visa. Extrusion is thought to be a techni- Xenograft tissues are readily available and less expensive cal failure from plug placement and rates are thought to than allografts cardizem 60mg with mastercard. Their primary drawback is that since they are decrease as one masters the learning curve buy 180 mg cardizem free shipping. This has not been demonstrated to be the case with in the intersphincteric space following fistula tract ligation. Initial studies demonstrated a 94 % cure rate at 15 months with minimal postoperative morbidity [26]. Surgisis sheets have also been used as interposition material after rectovagi- Cook Surgisis Plug nal fistula closure with success rates between 66 and 81% at 12 months [27 , 28]. The Cook Surgisis plug was released in 2006 and was the first commercially available fistula plug. The plug is completely type I collagen with a small amount of elastin as well as type degraded by host tissues over a period of 3 months [19, 20]. It is manufactured in two constructs, a porous Initial studies demonstrated an 83 % cure rate at 12 months sheet and milled fibers in saline suspension [29, 30 ]. However, because this comparing Permacol strips sutured into fistula tracts to the plug has been on the market the longest time, it is the plug milled fibers, suspended in fibrin glue, injected into the for which most data is available. At a median of two and a half years the suspension Multiple prospective, blinded studies have been carried group achieved an 80 % cure rate vs. This prospective cal errors led to an unacceptably high extrusion rate which randomized trial demonstrated a significant improvement in led to early plug failures [22]. We observed that over time the efficacy of plug or anal deformity rates between the two groups [32 ]. Also, interestingly, patients who received multiple plugs did significantly worse than those treated with a single plug Allograft (12. Long-term follow-up of that same cohort demonstrated and employed as fistula plugs. Because they are composed of a 51 % closure rate at 24 months indicating that those fistulae a variety of tissue types, including collagens, fibrin, elastin, that stayed closed at 6 months were likely to remain closed and glycosaminoglycans [33 , 34], it was initially thought that over the long term. These grafts all lack any cellular component which could potentially lead Considerations to rejection. The primary drawback associated with allograft use stems Crohn’s Disease from the scarcity of the product due to the manner in which is harvested. Cadaveric tissue is donated by the deceased Managing perineal Crohn’s disease can be very complicated, leading to a much greater cost when compared to easily requiring multiple interventions, and often exhausting the acquired xenograft sources. Few studies have looked specifically at patients with Crohn’s, however, a recent meta-analysis pooled similarly matched patients with and without Crohn’s Ruinuo Human Acellular Dermal Matrix and demonstrated similar fistula closure rates in both groups with usage of the Surgisis plug (54. Retrospective analysis Head-to-Head Comparisons of a prospective database demonstrated that 54. They demon- length of fistula, and procedure performed by an “expert” strated that in their hands 6 of 11 patients treated with the surgeon [36]. Healing rate for this procedure was comparisons are needed to determine which plugs may be the reported at 95 % at a median of 14 months with a mean time most efficacious; however there has always been resistance to resolution of approximately 2 weeks, however it is by industry to put forth these studies. Conclusions Despite mixed results thus far, the use of biologic agents, Lifecell Alloderm such as fibrin glue or fistula plugs have demonstrated some success. No large studies have been performed to date employ- to be performed, including head-to-head studies to identify ing Alloderm in closing complex anal fistulae, however sev- superiority. This is a constantly evolving field and new plugs eral case reports have been published in which Alloderm and new biologic agents are becoming available for use on a sheets were used interpositionally in a layered closure in regular basis. That place is likely in the 12 Biologic Fistula Plugs 87 patient who has a complex fistula or who has failed multiple 11. This is a therapy in its adversely affects the outcome of transanal advancement flap repair. Long-term results change conclusions on BioGlue in the treatment of high transsphincteric anal fistulas. Tract length predicts successful closure with anal the procedure-involving placement of the plug must then fistula plug in cryptoglandular fistulas. Surgical treatment of complex anal fistulas with being resistant to infection and extrusion. Efficacy of anal fistula plug in clo- sure of cryptoglandular fistulas: long-term follow-up. References Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula 1. Cirocchi R, Santoro A, Trastulli S, Farinella E, Di Rocco G, of transsphincteric and rectovaginal fistulas associated with Crohn’s Vendettuali D, et al. The use of fibrin nique for the closure of rectovaginal fistula using Surgisis mesh. Fibrin glue in the manage- in vivo cellular response to a cross-linked acellular collagen ment of anal fistulae. Management of idiopathic anal fistula using cross-linked collagen: Long-term outcomes of human acellular dermal matrix plug in a prospective phase 1 study. World of the intersphincteric fistula tract plus bioprosthetic anal fistula J Gastroenterol. Nanna with single tracts and carry a low risk of incontinence when Introduction treated. In contrast, a complex fistula involves greater than 30–50 % of the sphincter muscle; anterior in woman; or the the importance of understanding and treating anorectal patient has a history of preexisting incontinence, Crohn’s fistulae is evidenced not only by the prevalence of this condi- disease, or local irradiation [2 ]. There is When treating either type of fistula, maintaining fecal currently neither a consensus nor a set of guidelines on the continence is essentially tantamount to healing the fistula management of anorectal fistulae. Treatment included fistulotomy and marsu- fistulotomy with or without marsupialization, seton place- pialization (n=300), seton placement (n= 63), endorectal ment, and endorectal advancement flaps, each with variable advancement flap (n= 3), and other (n= 9). More recently, synthetic and biologic plugs 31 patients (8 %) and 45 % reported some degree of postop- have become available as adjuncts in fistula management. In this chapter, we discuss the available plugs, their chemical the traditional treatment of complex anal fistulas often composition, and contraindications to and recommended times involved advancement flaps. There is a wide variance techniques of application, including optimal disk placement. Jun and Choi reported an initial success rate We also review several studies with a focus on success and of 95 % (38 of 40) patients who underwent anocutaneous recurrence rates when using the Surgisis or Gore Bio-A plug. The study was a retrospective review of clearly define its indications and application. Sixty-two patients had anorectal fistulas while Anal fistula is one of the most frequently treated anorectal 37 patients had rectovaginal fistulas. The rate of primary diseases, with an estimated 10–30% of all colorectal inter- healing was found to be 63.

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Ultrasonographic appearance of normal phy include operator experience variability 180 mg cardizem mastercard, fetal position buy cheap cardizem, fetal globe at 20 weeks of gestation (coronal view) discount cardizem 60mg line. Retinoblastoma: at risk replicated epidemiologic data do not exist that suggest pregnancies. An additional invagination occurs that forms a groove fully characterize a finding from fetal ultrasonography, from the ventral aspect of the optic cup posteriorly to the and nondiagnostic prenatal ultrasonography. The anterior chamber absence of the eyes, the morphology of the lens and vitreous, angle, the stroma, and the endothelium covering the poste­ and performing ocular biometry. ЛИ were diagnosed would deliver enough radiation to justify termination of ultrasonographically with characteristic features including pregnancy. Three cases were unilateral,30 32 two of which were associated with contralateral microphthalmia. Associations included “anophthalmia-plus” syndrome,33ophthalmo-acromclic syn­ drome, type Waardenburg,14otocephaly," limb body wall complex,31 holoprosencephaly,17 a family history of anophthalmia,1"" and a maternal history of recurrent miscarriages. Clinically, the differentiation between anophthalmia and extreme microphthalmia is dif­ figure 11. Prenatal ultrasonographic characteristic features include an absent or small orbit, an absent globe, ana an absent lens. Nomograms for ocular biometric measurements based Gestational age at diagnosis has ranged from 14 to 32 weeks. Sixteen of the cases were associated with holoprosencephaly, 13 of which were alobar. The ocular diameter was demise;* the other case resulted in death shortly after birth. Causes include chromosomal aberrations, single gene mutations, and of other anomalies by ultrasonography (Fig. Gestational age at diagnosis the ocular globe at the insertion of the optic nerve. Note rocal showing proboscis (arrow), absent nasal bone, flat facial profile, and bulging of posterior pole of globe (arrow). Prenatal magnetic resonance imaging of optic nerve head cyclopia and proboscis in a fetus with normal chromosome at 13 weeks coloboma. Reproduced with permission of gestation by three-dimensional transabdominal sonography. Associations included trisomy punctata type I,70 Micro syndrome,71 trisomy 13,12 trisomy 13, trisomy 18, trisomy 21, microcephaly without chromo­ 21,72and a supernumerary chromosome from chromosome somal anomaly, fetal alcohol syndrome, and fetal exposure 21P Four of the cases did not report outcome. The fetus Appearance on ultrasonography is of a conical echogenicity with Micro syndrome was born at term and was noted post- within the globe with the base at the lens and the apex natally to also have microphthalmia. In the remaining five towards the retina,62 and an increased thickness of the cases, cataract extraction was performed postnatally/’5*9-7176 hyaloid artery-lens junction (Fig. Walkcr-Warbjrg syndrome, cataracts Cataract’ 14-34 Hyperecnogemc lens Microphthalmia,*4v- hypertelorism and macroglobus,>: malformation of :he anterior segment and retinal dysplasia, and anophthalmia1- Mldhr. The characteristic feature on ultrasonography is a conical structure with its base towards the lens and its apex point­ ing posteriorly toward the optic nerve. Two were associ­ ated with Walker-Warburg syndrome, 4,79 and one was associated with Norrie disease. Prenatal two cases; one fetus with Walker-Warburg syndrome was ultrasonographic characteristic feature are a conical echogenicity within stillborn at 38 weeks,78 and the fetus with Norrie disease the globe, with the base at the lens and the apex towards the retina, had a normal term delivery. Primary hypertelorism results from undermigration of the paired nasal swellings, resulting in the two halves of the face lying too far apart. Secondary hypertelorism usually results from abnormalities of the skull, including anterior cephaloccle and craniosynostoses. Prenatal ultrasonographic characteristic feature is hyperechogenicity of the lens. Г,хг One fetus had showing bilateral echogenic lenses corresponding to fetal cataract. Prenatal ultrasonographic diagnosis Two outcomes were reported; the fetus with 13 q syndrome of persistent hyperplastic primary vitreous. The first was detected by ultrasonography at 21 halves of the face lying too close together. This usually weeks as an irregular, echogenic mass, surrounded by a results in an anomaly in the spectrum of holoproscnccphaly. The abnormalities of the bony skull, including microcephaly and second case was detected at 38 weeks; retinoblastoma plagiocephaly. Apert syndrome Orbttal cyst1* 23-27 Cystic orbital m ass - Rhabdomyosarcoma-"4 34 Irregular, echo-dense orbital m ass - Teratoma13 17 Solid and cystic m ass with complex - echogenicity Dacryocystocele11в*вт-вом-в* 27-38 Hypoechoic m ass inferomedial to Polyhydramnios. One case was associated with microphthalmia, hydrocepha­ lus, ventricular septal defect, pericardial effusion, and V omphalocele. The other >1 case was associated with an enlarged urinary bladder and choroid plexus dysmorphism. Prenatal ultrasonographic diagnosed at 23 weeks using transabdominal and trans­ characteristic features are increased inner and outer orbital distances (hypertelorism) and decreased inner and outer orbital diameters vaginal ultrasound. Singh reported a Hypoteiorism: Two. The differential diagnosis of prenatal + cataract, prenatal + retinoblastoma,prenatal + retinal dacryocystocele includes enccphaloccle, nasal glioma, detachment, prenatal + hypertelorism, prenatal + hypotelorism, rhabdyomyosarcoma, dermoid cyst, and hemangioma. Case reports published between January 1, 1980, A variety of ocular, orbital, and adnexal abnormalities have and September 15, 2009, were included. The indications tal ultrasonographic screening: impact on the detection, management, for intrauterine screening for globe, orbit, and adnexal and outcom e of anom alous fetuses. Further research is needed to determine screening and perinatal m ortality: controlled trial of system atic one- the value of screening and its effect on management and stage screening in pregnancy. First and the English medical literature and the world medical litera- second-trim ester diagnosis of fetal ocular defects and associated anomalies: report o f eight cases. Axial growth of the fetal eye and prenatal + anophthalmia, prenatal + microphthalmia, prenatal + evaluation of the hyaloid artery: in utero ultrasonographic study. A case report o f prcnatally holoprosencephaly and cyclopia with triploidy by transvaginal three- diagnosed ophthalm o-acrom elic syndrom e type W aardenburg. U ltrasound dom inant cataracts of the fetus: early detection by transvaginal O bstet G ynecol 2005;25:629-30. Л large retinoblastom a facial dcfccts, am niotic bands, adhesions and upper lim b deficiency.

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